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ID 1418
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その他のタイトル(欧)
Antioxidant Activity and Hypoglycemic Effect of Ferulic Acid in STZ-induced Diabetic Mice and KK-A^y Mice
作成者
森下 比出子
大西 基代
松尾 貴子
谷口 久次
野村 英作
細田 朝夫
築野 卓夫
辻脇 里美
佐々木 秀行
Self DOI [info:doi/]
掲載誌名
和歌山大学教育学部紀要. 自然科学
ISSN
13424645
NCID
AN00257977
54
開始ページ
43
終了ページ
52
並び順
08
発行日
2004-02-27
本文言語
日本語
抄録(欧)
Antioxidant activity and biological properties of ferulic acid are well recognized. This study was designed to estimate the potential utility of ferulic acid administered orally at low dosage for improvement of hyperglycemia in diabetes. With this aim we have evaluated the hypoglycemic effect of ferulic acid in two type diabetic animal models: (1) streptozotocin (STZ)-induced diabetic mice, a model of insulin-dependent diabetes mellitus (IDDM); (2) KK-A^y mice, a model of non-insulin dependent diabetes mellitus (NIDDM). In addition, we measured the production of TEARS in liver, kidney and brown adipose tissues of diabetic mice at the end of ferulic acid feeding experiment. Ferulic acid at 0.01% and 0.1% of basal diet showed to suppress significantly blood glucose levels in STZ-induced diabetic mice. In KK-A^y mice 0.05% ferulic acid suppressed effectively blood glucose levels. In addition, ferulic acid inhibited the lipid peroxidation in liver, kidney and brown adipose tissue of diabetic mice. Taken together, these findings suggest that dietary ferulic acid may be useful in alleviating oxidative stress and attenuating the hyperglycemic response associated with diabetes.
資料タイプ
紀要論文
著者版フラグ
出版者版
アクセション番号
KJ00004258258