ID | 1418 |
フルテキストファイル | |
その他のタイトル(欧) | Antioxidant Activity and Hypoglycemic Effect of Ferulic Acid in STZ-induced Diabetic Mice and KK-A^y Mice
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作成者 |
森下 比出子
大西 基代
松尾 貴子
谷口 久次
野村 英作
細田 朝夫
築野 卓夫
辻脇 里美
佐々木 秀行
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Self DOI [info:doi/] | |
掲載誌名 |
和歌山大学教育学部紀要. 自然科学
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ISSN | 13424645
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NCID | AN00257977
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巻 | 54
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開始ページ | 43
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終了ページ | 52
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並び順 | 08
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発行日 | 2004-02-27
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本文言語 |
日本語
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抄録(欧) | Antioxidant activity and biological properties of ferulic acid are well recognized. This study was designed to estimate the potential utility of ferulic acid administered orally at low dosage for improvement of hyperglycemia in diabetes. With this aim we have evaluated the hypoglycemic effect of ferulic acid in two type diabetic animal models: (1) streptozotocin (STZ)-induced diabetic mice, a model of insulin-dependent diabetes mellitus (IDDM); (2) KK-A^y mice, a model of non-insulin dependent diabetes mellitus (NIDDM). In addition, we measured the production of TEARS in liver, kidney and brown adipose tissues of diabetic mice at the end of ferulic acid feeding experiment. Ferulic acid at 0.01% and 0.1% of basal diet showed to suppress significantly blood glucose levels in STZ-induced diabetic mice. In KK-A^y mice 0.05% ferulic acid suppressed effectively blood glucose levels. In addition, ferulic acid inhibited the lipid peroxidation in liver, kidney and brown adipose tissue of diabetic mice. Taken together, these findings suggest that dietary ferulic acid may be useful in alleviating oxidative stress and attenuating the hyperglycemic response associated with diabetes.
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資料タイプ |
紀要論文
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著者版フラグ |
出版者版
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アクセション番号 | KJ00004258258
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