ID | 1418 |
FullText File | |
Title Alternative | Antioxidant Activity and Hypoglycemic Effect of Ferulic Acid in STZ-induced Diabetic Mice and KK-A^y Mice
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Authors |
Morishita, Hideko
Ohnishi, Motoyo
Matuo, Takako
Taniguchi, Hisaji
Nomura, Eisaku
Hosoda, Asao
Tsuno, Takuo
Tsujiwaki, Satomi
Sasaki, Hideyuki
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Self DOI | |
Journal Title |
Bulletin of the Faculty of Education, Wakayama University. Natural science
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ISSN | 13424645
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NCID | AN00257977
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Volume | 54
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Start Page | 43
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End Page | 52
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Order | 08
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Published Date | 2004-02-27
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Language |
jpn
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Abstract Alternative | Antioxidant activity and biological properties of ferulic acid are well recognized. This study was designed to estimate the potential utility of ferulic acid administered orally at low dosage for improvement of hyperglycemia in diabetes. With this aim we have evaluated the hypoglycemic effect of ferulic acid in two type diabetic animal models: (1) streptozotocin (STZ)-induced diabetic mice, a model of insulin-dependent diabetes mellitus (IDDM); (2) KK-A^y mice, a model of non-insulin dependent diabetes mellitus (NIDDM). In addition, we measured the production of TEARS in liver, kidney and brown adipose tissues of diabetic mice at the end of ferulic acid feeding experiment. Ferulic acid at 0.01% and 0.1% of basal diet showed to suppress significantly blood glucose levels in STZ-induced diabetic mice. In KK-A^y mice 0.05% ferulic acid suppressed effectively blood glucose levels. In addition, ferulic acid inhibited the lipid peroxidation in liver, kidney and brown adipose tissue of diabetic mice. Taken together, these findings suggest that dietary ferulic acid may be useful in alleviating oxidative stress and attenuating the hyperglycemic response associated with diabetes.
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Content Type |
Departmental Bulletin Paper
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Text Version |
publisher
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Accession No. | KJ00004258258
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